I'm fairly pumped about this company (PolarityTE), who just got registered/approved by the FDA for their skinTE technology. Basically they have proven total scarless skin regeneration (all layers + hair). They will be starting trials on more extreme cases by the end of the year. Their roadmap also includes nerve/capillary/fat/bone regeneration in the coming years. https://globenewswire.com/news-release/2017/10/03/1140038/0/en/PolarityTE-Announces-FDA-Registration-of-Lead-Product-SkinTE.htmlBiotech is growing fast lately!
BACKGROUND:Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity. Remodeling of the condyle and temporal fossa with destruction of condylar cartilage and subchondral bone leads to postsurgical condylar resorption, with arthralgia and functional limitations. Patients with severe lesions are refractory to conservative treatments, leading to more invasive therapies that range from simple arthrocentesis to open surgery and prosthesis. Although aggressive and with a high risk for the patient, surgical invasive treatments are not always efficient in managing the degenerative lesions.METHODS:We propose a regenerative medicine approach using in-vitro expanded autologous cells from nasal septum applied to the first proof-of-concept patient. After the required quality controls, the cells were injected into each joint by arthrocentesis. Results were monitored by functional assays and image analysis using computed tomography.RESULTS:The cell injection fully reverted the condylar resorption, leading to functional and structural regeneration after 6 months. Computed tomography images showed new cortical bone formation filling the former cavity space, and a partial recovery of condylar and temporal bones. The superposition of the condyle models showed the regeneration of the bone defect, reconstructing the condyle original form.CONCLUSIONS:We propose a new treatment of condylar resorption subsequent to orthognathic surgery, presently treated only by alloplastic total joint replacement. We propose an intra-articular injection of autologous in-vitro expanded cells from the nasal septum. The proof-of-concept treatment of a selected patient that had no alternative therapeutic proposal has given promising results, reaching full regeneration of both the condylar cartilage and bone at 6 months after the therapy, which was fully maintained after 1 year. This first case is being followed by inclusion of new patients with a similar pathological profile to complete an ongoing stage I/II study.
https://www.sciencedaily.com/releases/2018/08/180801115229.htmThoughts?
Too optimistic? https://www.youtube.com/watch?v=YwHRjA5L4FA
He says they can grow organs.Where is this happening? A lab?
In Lazlo's pants.
