Got posted here years ago:
https://jawsurgeryforums.com/index.php/topic,6235.msg51275.html#msg51275An Israeli company recently announced success where they injected bioractor grow autologous bone grafts into the jaws of a few patients in the maxillofacial region. Here's the website describing the product.
A product like this certainly looks great for grafting osteotomy defects. I wonder whether it might also be useful in non-invasive facial augmentation, particularly in the infraorbital region under the eye which is hard to hit surgically and causes the dreaded eye bags a lot of us get early. I don't know if there might be some fundamental limitations, I don't see how an augmentation would be added under a soft tissue attachment point for example. For those we'd need a treatment that stimulates growth of existing bone. Like re-opening the sutures closed from childhood.
Has anybody heard something from them since? From what I can find on google, it's currently stuck in Phase II trial?
https://bonus-bio.com/index.php/science-and-medicine/bonofillhttps://www.sciencedirect.com/science/article/abs/pii/S1465324920307362https://sci-hub.hkvisa.net/10.1016/j.jcyt.2020.03.491
Apparently they're gonna do a webinar in a week (link:
https://us06web.zoom.us/webinar/register/5816660875037/WN_UZsRfZKgRmWrXft2inu_bg). It seems however that it's not gonna be in english.
From the abstract of the paper of the Phase IIa trial:
The gold standard for bone regeneration of bone deficiencies is still an autologous bone graft, which has considerable disadvantages; namely, the need for a second major surgery and the limited volume of bone available for harvesting. BonoFill (BF) is a novel, tissue-engineered, bone graft with intrinsic osteoinductive, osteoconductive, and osteogenic properties, consisting of the patient's own adipose tissue-derived mesenchymal stem cells, attached to hydroxyapatite particles. Here, we present the safety and efficacy results of BF first-in-human clinical study for maxillofacial bone tissue regeneration.
The study results demonstrated that BF promoted adequate bone tissue regeneration without complications. Per our evaluation, there were no incidents of chronic bone infection, or significant changes in complete blood count, and the patients reported overall good health for the duration of the study. At trial end, in the sinus augmentation indication, the BF treated sites residual bone was augmented at an average of 6.36 mm (Δ new bone, n = 10) and the total bone height at the treated area was on average 11.44 mm (n = 10). In the indication of filling of bone voids, the patient's average residual bone height of 2.91 mm was 15.76 mm (n = 1) at trial end.
BF treatment was shown to be safe and resulted in newly generated bone, which provided adequate bone height for placement of dental implants. Thus, BF is a promising novel autologous bone graft for bone tissue repair.
What do you guys think, could this become a thing in the future or is this a full blown scam? Sounds a bit too good to be true, doesn't it?
